Onco-Nephrology: Tumor Lysis Syndrome

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Onco-nephrology: tumor lysis syndrome.

Tumor lysis syndrome (TLS) describes the clinical and laboratory sequelae that result from the rapid release of intracellular contents of dying cancer cells. It is characterized by the release of potassium, phosphorous, and nucleic acids from cancer cells into the blood stream, with the potential to cause hyperkalemia; hyperphosphatemia and secondary hypocalcemia; hyperuricemia; AKI; and, shoul...

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Onco-nephrology: Core Curriculum 2015.

From Zablocki VAMC, Medical College of Wisconsin, Milwaukee, WI; CHU Université de Liège, Liège, Belgium; Hôpital de la Salpetrière, Paris, France; and Katholieke Universiteit Leuven, Leuven, Belgium. Received January 20, 2015. Accepted in revised form April 6, 2015. Originally published online June 6, 2015. Current affiliation: Baltimore VAMC and the University of Maryland School of Medicine, ...

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Tumor Lysis Syndrome

Hospital Physician September 2008 25 T umor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur as a result of the release of intracellular contents following lysis of malignant cells, typically after initiation of chemotherapy. The features of TLS include hyperphosphatemia, hyperuricemia, hypocalcemia, hyperkalemia, and acute kidney injury. These features are observed wh...

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Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare. This case study is of a 62-year-old female admitted with multisystem organ failure, with subsequent diagnosis of aggressive B cell lymphoma. On admission, labo...

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The tumor lysis syndrome.

From the Department of Oncology and International Outreach Program, St. Jude Children’s Research Hospital (S.C.H., C.-H.P.), and the Department of Pediatrics, University of Tennessee Health Sciences Center, College of Medicine (S.C.H., D.P.J., C.-H.P.) — both in Memphis. Address reprint requests to Dr. Howard at St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Barry-Longinotti Bld...

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ژورنال

عنوان ژورنال: Clinical Journal of the American Society of Nephrology

سال: 2012

ISSN: 1555-9041,1555-905X

DOI: 10.2215/cjn.03150312